Done By Hollis, Lori, and Luis
Hollis S.
Researchers at Stanford University have been able to reverse diabetes in mice. Mouse stem cells were implanted into rats embryos. The rats were genetically engineered to be unable to develop their own pancreas, so they had to rely on the mouse cells to develop one. After the rats had fully grown, the researchers transplanted islets from their pancreases into mice the stem cells came from. The mice had been given a drug that caused them to develop diabetes. The diabetic mice’s blood glucose levels remained normal for over a year after the transplantation of as few as 100 islets. Additionally, the mice needed only five days of immunosuppressive therapy to prevent rejection of the organs.
Conger, K. (20`17, January). Rat-grown mouse pancreases help reverse diabetes in mice. Retrieved April 13, 2017, from https://med.stanford.edu/news/all-news/2017/01/rat-grown-mouse-pancreases-help-reverse-diabetes-in-mice.html
Luis Flores -
Other animals that are also used for the research of diabetes include
Dogs
Dogs, just like humans, can contract diabetes. The condition can have similar effects on the animal
- Blindness
- Change in appetite
- Weight loss
- High Blood Sugar
- Excessive thirst
- Shortening of Life Span
The fact that dogs could develop diabetes was first discovered in 1889 by Oskar Minkowski and Joseph von Mering when they removed the pancreas from a dog.
The first test on a dog to find treatment for Diabetes (before that, Diabetes was considered fatal) was conducted with pancreatic extracts injected into one. The result was that most of the symptoms of diabetes were alleviated, and the treatment with the extracts were later produced from cattle.
Lori Ko- The Goto-Kakizaki (GK) rats is considered as one of the best non-obese type 2 diabetic animal model. The cell dysfunction and apoptosis are acknowledged as a major reason of insufficient insulin secretion. This is in response to high blood glucose and metabolic demand. As a consequence, type 2 diabetes mellitus (T2DM) is known to occur. They have characteristic that are both more or less common, and are present in human diabetic patients. This animal model is considered appropriate to inspect various pathologic mechanisms of T2DM. This might help to investigate various aspects of spontaneous T2DM.
Akash, M. S., Rehman, K., & Chen, S. (2013, September). Goto-Kakizaki rats: its suitability as non-obese diabetic animal model for spontaneous type 2 diabetes mellitus. Retrieved April 13, 2017, from https://www.ncbi.nlm.nih.gov/pubmed/23855509
Researchers at Stanford University have been able to reverse diabetes in mice. Mouse stem cells were implanted into rats embryos. The rats were genetically engineered to be unable to develop their own pancreas, so they had to rely on the mouse cells to develop one. After the rats had fully grown, the researchers transplanted islets from their pancreases into mice the stem cells came from. The mice had been given a drug that caused them to develop diabetes. The diabetic mice’s blood glucose levels remained normal for over a year after the transplantation of as few as 100 islets. Additionally, the mice needed only five days of immunosuppressive therapy to prevent rejection of the organs.
Conger, K. (20`17, January). Rat-grown mouse pancreases help reverse diabetes in mice. Retrieved April 13, 2017, from https://med.stanford.edu/news/all-news/2017/01/rat-grown-mouse-pancreases-help-reverse-diabetes-in-mice.html
Luis Flores -
Other animals that are also used for the research of diabetes include
Dogs
Dogs, just like humans, can contract diabetes. The condition can have similar effects on the animal
- Blindness
- Change in appetite
- Weight loss
- High Blood Sugar
- Excessive thirst
- Shortening of Life Span
The fact that dogs could develop diabetes was first discovered in 1889 by Oskar Minkowski and Joseph von Mering when they removed the pancreas from a dog.
The first test on a dog to find treatment for Diabetes (before that, Diabetes was considered fatal) was conducted with pancreatic extracts injected into one. The result was that most of the symptoms of diabetes were alleviated, and the treatment with the extracts were later produced from cattle.
Lori Ko- The Goto-Kakizaki (GK) rats is considered as one of the best non-obese type 2 diabetic animal model. The cell dysfunction and apoptosis are acknowledged as a major reason of insufficient insulin secretion. This is in response to high blood glucose and metabolic demand. As a consequence, type 2 diabetes mellitus (T2DM) is known to occur. They have characteristic that are both more or less common, and are present in human diabetic patients. This animal model is considered appropriate to inspect various pathologic mechanisms of T2DM. This might help to investigate various aspects of spontaneous T2DM.
Akash, M. S., Rehman, K., & Chen, S. (2013, September). Goto-Kakizaki rats: its suitability as non-obese diabetic animal model for spontaneous type 2 diabetes mellitus. Retrieved April 13, 2017, from https://www.ncbi.nlm.nih.gov/pubmed/23855509