Lori Ko- The Goto-Kakizaki (GK) rats is considered as one of the best non-obese type 2 diabetic animal model. The cell dysfunction and apoptosis are acknowledged as a major reason of insufficient insulin secretion. This is in response to high blood glucose and metabolic demand. As a consequence, type 2 diabetes mellitus (T2DM) is known to occur. They have characteristic that are both more or less common, and are present in human diabetic patients. This animal model is considered appropriate to inspect various pathologic mechanisms of T2DM. This might help to investigate various aspects of spontaneous T2DM.
Akash, M. S., Rehman, K., & Chen, S. (2013, September). Goto-Kakizaki rats: its suitability as non-obese diabetic animal model for spontaneous type 2 diabetes mellitus. Retrieved April 13, 2017, from https://www.ncbi.nlm.nih.gov/pubmed/23855509
Akash, M. S., Rehman, K., & Chen, S. (2013, September). Goto-Kakizaki rats: its suitability as non-obese diabetic animal model for spontaneous type 2 diabetes mellitus. Retrieved April 13, 2017, from https://www.ncbi.nlm.nih.gov/pubmed/23855509