Luis F. - Dogs
Dogs, just like humans, can contract diabetes. The condition can have similar effects on the animal
- Blindness
- Change in appetite
- Weight loss
- High Blood Sugar
- Excessive thirst
- Shortening of Life Span
The fact that dogs could develop diabetes was first discovered in 1889 by Oskar Minkowski and Joseph von Mering when they removed the pancreas from a dog.
The first test on a dog to find treatment for Diabetes (before that, Diabetes was considered fatal) was conducted with pancreatic extracts injected into one. The result was that most of the symptoms of diabetes were alleviated, and the treatment with the extracts were later produced from cattle.
The discovery of insulin took place on a test ON A DOG. It was the same test that was done by Oskar Minkowski
Research on dog diabetes has also helped the advancement of Diabetes research in humans.
- The main research done on dogs is gene therapy. This involves producing viruses in the body of a dog to ultimately produce insulin by their side effects.
Researchers physically caused effects of type 1 diabetes by destroying their beta cells, cells that are located in the pancreas that produce insulin with a certain drug. They used viral vectors to insert "the gene for insulin and the gene for glucokinase (an enzyme that attaches a phosphate molecule to glucose)" into the muscles of the dogs, which where beagles. Glucokinase, which produces phosphorylated glucose, acted as a glucose sensor, which told the muscles how much insulin to release into the bloodstream based on glucose levels.
- Gladly, the test was a success. The dogs lived, for the next four years, healthy lives with normal blood sugar levels.
The only downside is that the type 1 diabetes that dogs have is not the same as ours. But it was a great improvement in research, helping the development for a cure in the years to come
Citations:
- (n.a) Researchers Used Gene Therapy to Cure Diabetes in Dogs. (2013, October 7). Retrieved April 26, 2017, from http://www.diabetes.org/research-and-practice/patient-access-to-research/researchers-used-gene-therapy.html?referrer=https%3A%2F%2Fwww.google.com%2F
- David, Diabetes Research Helps People and Dogs. (2016, July 21). Retrieved April 26, 2017, from https://fbresearch.org/diabetes-research-helps-people-dogs/
Dogs, just like humans, can contract diabetes. The condition can have similar effects on the animal
- Blindness
- Change in appetite
- Weight loss
- High Blood Sugar
- Excessive thirst
- Shortening of Life Span
The fact that dogs could develop diabetes was first discovered in 1889 by Oskar Minkowski and Joseph von Mering when they removed the pancreas from a dog.
The first test on a dog to find treatment for Diabetes (before that, Diabetes was considered fatal) was conducted with pancreatic extracts injected into one. The result was that most of the symptoms of diabetes were alleviated, and the treatment with the extracts were later produced from cattle.
The discovery of insulin took place on a test ON A DOG. It was the same test that was done by Oskar Minkowski
Research on dog diabetes has also helped the advancement of Diabetes research in humans.
- The main research done on dogs is gene therapy. This involves producing viruses in the body of a dog to ultimately produce insulin by their side effects.
Researchers physically caused effects of type 1 diabetes by destroying their beta cells, cells that are located in the pancreas that produce insulin with a certain drug. They used viral vectors to insert "the gene for insulin and the gene for glucokinase (an enzyme that attaches a phosphate molecule to glucose)" into the muscles of the dogs, which where beagles. Glucokinase, which produces phosphorylated glucose, acted as a glucose sensor, which told the muscles how much insulin to release into the bloodstream based on glucose levels.
- Gladly, the test was a success. The dogs lived, for the next four years, healthy lives with normal blood sugar levels.
The only downside is that the type 1 diabetes that dogs have is not the same as ours. But it was a great improvement in research, helping the development for a cure in the years to come
Citations:
- (n.a) Researchers Used Gene Therapy to Cure Diabetes in Dogs. (2013, October 7). Retrieved April 26, 2017, from http://www.diabetes.org/research-and-practice/patient-access-to-research/researchers-used-gene-therapy.html?referrer=https%3A%2F%2Fwww.google.com%2F
- David, Diabetes Research Helps People and Dogs. (2016, July 21). Retrieved April 26, 2017, from https://fbresearch.org/diabetes-research-helps-people-dogs/